CHARGED POLYSACCHARIDES RESISTANT TO LYSOSOMAL DEGRADATION DURING KIDNEY FILTRATION AND RENAL PASSAGE AND THEIR USE TO TREAT OR PREVENT INFECTION BY CORONAVIRUSES

摘要

This invention relates to methods for treating, preventing or managing coronavirus infections in mammals using sulfated polysaccharides. More particularly, this invention relates to methods of treating, preventing or managing infection by coronaviruses, particularly viral infections leading to or causing diseases such as the newly discovered Severe Acute Respiratory Syndrome ("SARS"). The invention involves the use of sulfated polysaccharides which are abundant, non-toxic and inexpensive and which are potent antivirals in vivo.