PREVENTIVE AND/OR THERAPEUTIC AGENT FOR NEUTROPHIL INFLAMMATION DISEASE

摘要

A preventive and/or therapeutic agent for neutrophil inflammation disease, comprising as an active ingredient a substance capable of inhibiting the function relating to GPR4 signal transmission. In particular, a preventive and/or therapeutic agent for neutrophil inflammation disease, comprising a nitrogenous tricyclic compound of the formula (I): [wherein R<1> is a substituted or unsubstituted heterocyclic group, etc.; R<2> is hydrogen, a substituted or unsubstituted lower alkyl, etc.; each of R<3> and R<4> independently is hydrogen, a lower alkyl, etc.; n is 0 or 1; X is -(CH2)2-, etc.; and Y is represented by the formula: (A) (wherein W is CH or a nitrogen atom; each of Z<1> and Z<2> independently is hydrogen, a substituted or unsubstituted lower alkyl, etc.; and Z<3> is hydrogen, a substituted or unsubstituted lower alkyl, etc.)], or a quaternary ammonium salt of the same or a pharmacologically acceptable salt thereof.