发明名称 |
Neutrokine-alpha polypeptides |
摘要 |
The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders. |
申请公布号 |
US6812327(B1) |
申请公布日期 |
2004.11.02 |
申请号 |
US20000507968 |
申请日期 |
2000.02.22 |
申请人 |
HUMAN GENOME SCIENCES, INC. |
发明人 |
YU GUO-LIANG;EBNER REINHARD;NI JIAN;ROSEN CRAIG A. |
分类号 |
A61K38/00;C07H21/04;C07K14/52;C07K14/715;C07K16/24;C12P21/08;(IPC1-7):A61K38/16;C07K2/00;C07K14/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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