发明名称 |
Method of identifying inhibitors of EBNA-1 |
摘要 |
A method of assaying potential inhibitors of EBNA-1 is disclosed. In one aspect, this invention comprises the steps of (a) obtaining an EBV-positive cell line and an EBV-negative cell line; (b) exposing the cell lines to a test compound, and (c) observing the effect of the compound on induction of apoptosis in the cell lines, wherein significant apoptosis in the EBV-positive cell line and lack of significant apoptosis in the EBV-negative cell line indicates a compound that specifically inhibits EBNA-1.
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申请公布号 |
US6811983(B2) |
申请公布日期 |
2004.11.02 |
申请号 |
US20020201887 |
申请日期 |
2002.07.24 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
SUGDEN WILLIAM M.;KOMANO ATSUSHI JUN;KENNEDY GREGORY |
分类号 |
C12Q1/18;(IPC1-7):C12Q1/68 |
主分类号 |
C12Q1/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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