| 摘要 |
<p>The invention discloses a novel compound of the benzofuroxan series used for cardiovascular disorders represented by the general formula (I)and pharmaceutically acceptable salts thereofwherein:R is -O-(CH2)n-X-R';n=1 to 6;X is -NHC(O)-, or oxygen;R' is lower alkyl (C1-C8), aromatic, heteroaromatic, substituted or unsubstituted saturated heterocyclic ring with one or two hetero atoms such as nitrogen or oxygen wherein substitution is with lower alkyl;or R is selected fromwherein R'' is hydrogen, nitro, lower alkyl or-C(O)-R'''wherein R''' is hydrogen, lower alkyl or aryl.The invention also discloses process for the preparation of compounds of general formula I.The invention also discloses the use of the compounds of general formula I as defined above, as NO donors and/or in coronary heart diseases, and pharmaceutical compositions containing compounds of general formula I as active ingredients.The invention also discloses a method of treatment of mammal, including man, of coronary heart disease by administration of an effective amount of a compound of formula I as defined above.</p> |
