| 发明名称 |
HETEROCICLOS BICICLICOS DISSUBSTITUIDOS COM EFEITO ESPECIAL DE INIBICAO DA TROMBINA |
| 摘要 |
Novel disubstituted bicyclic heterocycles, of which the following are exemplary: (a) 1-methyl-2-[(4-amidinophenyl)-oxymethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole, (b) 1-methyl-2-[2-(4-amidinophenyl)-ethyl]-5-[N-(N-(hydroxycarbonylmethyl)-aminocarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole, (c) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole and (d) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-indole. These are useful for the treatment of thrombotic disease. |
| 申请公布号 |
PT1100795(E) |
申请公布日期 |
2004.10.29 |
| 申请号 |
PT19990938353T |
申请日期 |
1999.07.27 |
| 申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG |
发明人 |
GERHARD MIHM;RAINER ZIMMERMANN;HENNING PRIEPKE;JEAN MARIE STASSEN;UWE RIES;NORBERT HAUEL;KLAUS BINDER;WOLFGANG WIENEN |
| 分类号 |
A61K31/4184;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4439;A61K31/4709;A61K31/4725;A61P7/02;C07D215/38;C07D215/40;C07D235/12;C07D235/14;C07D235/16;C07D235/28;C07D307/81;C07D401/12;C07D401/14;C07D405/12;C07D405/14;C07D409/14;C07D413/12;C07D417/12;C07D471/04;(IPC1-7):C07D401/12 |
主分类号 |
A61K31/4184 |
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