Heteroaryl alkyl piperazine derivatives as fatty acid oxidation inhibitors

摘要

Disclosed are piperazine compounds of formula (I), wherein: m = 1, 2 or 3, q = NH, O or S, R1, R2, R3, R4 and R5 are each independently selected from H, OR20 and straight or branched alkyl, R6, R7 and R8 are H, R9, R10, R11, R12, R13, R14, R15 and R16 are independently selected from H, straight or branched alkyl, or wherein R9 and R10 may together form carbonyl, or R11 and R12 may together form a carbonyl, or R13 and R14 may together form a carbonyl, or R15 or R16 may together form a carbonyl, R17 is selected from benzoxazolyl, benzthiazolyl, quinoxalinyl, pyridinyl, quinolinyl, isoquinolinyl, and indolyl, wherein each group is optionally substituted with 1-3 substituents selected from CON(R20)2, straight or branched alkyl and aryl, wherein the aryl substituents are optionally substituted with CF3, and R20 is hydrogen. The compounds are used for the manufacture of medicaments for the treatment of a disease state in a mammal that is alleviated by treatment with a partial fatty acid oxidation inhibitor.