Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors

摘要

The invention provides compounds which are PDE7inhibitors, having the following formula (I), (II) and (III) in which X1, X2, X3, X4, X, Y, Z, A and Z<1 >are as defined in the description, methods for preparing them and their use for the treatment of disorders for which therapy by a PDE7 inhibitor is relevant.