发明名称 |
DETECTION OF NUCLEIC ACID SEQUENCES BY CLEAVAGE AND SEPARATION OF TAG-CONTAINING STRUCTURES |
摘要 |
The present invention is directed to a method of detecting pluralities of target nucleic acid sequences by forming and cleaving duplex structures with a pair of probes, one probe of each pair being labeled with an electrophoretic tag. Cleavage of the duplex structures releases electrophoretic tags that are then separated and identified to indicate the presence or quantity of the target sequences. The present invention is particularly useful in multiplex reactions wherein multiple target sequences are detected in one reaction. Kits useful in the detection of nucleic acids are also provided. |
申请公布号 |
WO03042657(A3) |
申请公布日期 |
2004.10.28 |
申请号 |
WO2002US35552 |
申请日期 |
2002.11.06 |
申请人 |
ACLARA BIOSCIENCES INC. |
发明人 |
CHENNA, AHMED;XIAO, VIVIAN;SINGH, SHARAT |
分类号 |
G01N27/447;C07H19/10;C07H19/20;C07H21/00;C12N15/09;C12Q1/34;C12Q1/68;C40B30/00 |
主分类号 |
G01N27/447 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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