Preparation of alkyl 6-hydroxycaproate from alkyl pentenoate comprises hydroformylation to formylvalerate then hydrogenation and separation from mixture of hydroxycarboxylates formed

摘要

Alkyl 6-hydroxycaproates (I) preparation comprises reacting alkyl 2-, 3- and/or 4-pentenoates (II) with carbon monoxide and hydrogen to form 3-, 4- and 5-formylvalerates (III); hydrogenating and separating (I) from alkyl 6C hydroxycarboxylates (IV) produced. First step is in presence of rhodium compound and tertiary organic polyphosphite (A) and the hydrogenation uses catalyst from subgroup I or VI-VIII. Preparation of alkyl 6-hydroxycaproates (I) comprises reacting alkyl 2-, 3- and/or 4-pentenoates (II) with carbon monoxide and hydrogen to form a mixture consisting mainly of 3-, 4- and 5-formylvalerates (III); hydrogenating this mixture and separating (I) from the mixture of alkyl 6C hydroxycarboxylates (IV) produced. The first step is in presence of a rhodium compound and a tertiary organic polyphosphite (A) and the hydrogenation is in the presence of a catalyst containing at least one element of subgroup I or VI-VIII.