MOUSE WITH DEFICIENCY OF GLUTAMATE TRASNPORTER GLAST FUNCTION

摘要

It is intended to provide a GLAST knockout mouse lacking the function of endogenous glutamate transporter GLAST gene which shows: 1) an ocular tensio n within the normal range; and 2) a decrease in retinal ganglion cell count compared with a normal wild type mouse. Owing to the ocular properties, this knockout mouse is useful as a normal tension glaucoma model. By using this knockout mouse, a compound useful in treating normal tension glaucoma can be screened.