| 摘要 |
PROBLEM TO BE SOLVED: To provide a new quinoline, tetrahydroquinazoline, and pyrimidine derivative and method of treatment related to the use thereof. SOLUTION: The present invention relates to new compounds of formula (I), which act as MCH receptor antagonists. The compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction. COPYRIGHT: (C)2005,JPO&NCIPI
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