METHOD FOR DETECTING GENE BASED ON HUMAN MITOCHONDRIAL GENE MUTATION

摘要

PROBLEM TO BE SOLVED: To provide a method for detecting a gene, giving useful information for determination on whether or not some persons may suffer from Parkinson's disease or whether or not some persons may become health and long-lived based on searching mitochondrial genomic polymorphisms associated with persons of 100-year old and patients with Parkinson's disease. SOLUTION: A mitochondrial genomic whole base sequence is analyzed by a direct base sequence determination method in each of 96 persons of 100-year old and patients with Parkinson's disease. Consequently, a total of 557 mutations are confirmed in the patients with Parkinson's disease[ 348 mutations in the coding region( 244 multiple substitutions and 104 non-multiple substitutions )] and a total of 519 mutations in the persons of 100-year old[ 327 mutations in the coding region( 231 multiple substitutions and 96 non-multiple substitutions )]. Analysis of these mutations in details enables mutations involved in health and longevity to be identified. COPYRIGHT: (C)2005,JPO&NCIPI