发明名称 |
N-ALKYL-HYDROXAMIC ACID-ISOINDOLYL COMPOUNDS AND THEIR PHARMACEUTICAL USES |
摘要 |
The invention encompasses novel N-alkyl-hydroxamic acid-isoindolyl compounds of formula (I) with the definition X1-X4, Z1, Z2, R1, R2, R7 and Y according to claim 1, pharmaceutical compositions of these compounds, and methods of using these compounds and compositions for treatment or prevention of various diseases and disorders mediated by PDE4 inhibition, associated with abnormal TNA-alpha levels, and/or mediated by MMP inhibition. |
申请公布号 |
WO2004080422(A3) |
申请公布日期 |
2004.10.28 |
申请号 |
WO2004US07742 |
申请日期 |
2004.03.12 |
申请人 |
CELGENE CORPORATION;MAN, HON-WAH;MULLER, GEORGE, W. |
发明人 |
MAN, HON-WAH;MULLER, GEORGE, W. |
分类号 |
A61K31/4035;A61K31/4178;A61K31/4196;A61K31/4245;A61K31/454;A61K31/496;A61K31/5377;C07D209/46;C07D209/48;C07D413/02;C07D417/02 |
主分类号 |
A61K31/4035 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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