摘要 |
The present invention provides a kit and a method for targeting of a diagnostic or therapeutic agent to a target site in a mammal having a pathological condition. The kit comprises, in separate containers, (A) a first conjugate comprising a targeting moiety and a Morpholino oligomer, wherein said targeting moiety selectively binds to a primary, target-specific binding site of the target site or to a substance produced by or associated with the target site; (B) optionally, a clearing agent; (C) a second conjugate comprising multiple copies of complementary Morpholino oligomer and a diagnostic agent or therapeutic agent; wherein said complementary Morpholino oligomer is bound to a polymer; and (D) a third conjugate comprising a Morpholino oligomer and a radiolabel. The method comprises administering (A), optionally (B), (C) and (D) to a mammal. |
申请人 |
IMMUNOMEDICS, INC.;HNATOWICH, DONALD J.;HE, JIANG;LIU, GUOZHENG;GUPTA, SURESH;ZHANG, YUMIN;RUSCKOWSKI, MARY |
发明人 |
HNATOWICH, DONALD J.;HE, JIANG;LIU, GUOZHENG;GUPTA, SURESH;ZHANG, YUMIN;RUSCKOWSKI, MARY |