发明名称 |
STIMULATION DES KNORPELWACHSTUMS MIT AGONISTEN DES NICHT-PROTEOLYTISCH AKTIVIERTEN THROMBIN REZEPTORS |
摘要 |
Disclosed is a method of stimulating cartilage growth, repair or regeneration at a site in a subject in need of such growth, repair or regeneration. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.Also disclosed is a method of stimulating the proliferation and expansion of chrondrocytes in vitro. The method comprises culturing chrondrocytes in the presence of a stimulating amount of an NPAR agonist. |
申请公布号 |
DE60105772(D1) |
申请公布日期 |
2004.10.28 |
申请号 |
DE2001605772 |
申请日期 |
2001.07.19 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
CARNEY, H.;CROWTHER, S.;STIERNBERG, JANET;BERGMANN, JOHN |
分类号 |
C12N9/74;A61K35/32;A61K38/00;A61K38/17;A61K38/46;A61K38/48;A61K45/00;A61K47/34;A61L27/00;A61L27/18;A61L27/22;A61L27/54;A61P17/02;A61P19/00;A61P19/02;A61P19/08;A61P43/00;C12N5/06;(IPC1-7):C12N15/00;A61L27/14;A61L27/38;C12N5/08 |
主分类号 |
C12N9/74 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|