发明名称 |
METHODS OF IDENTIFYING COMPOUNDS THAT MODULATE A DNA REPAIR PATHWAY AND/OR RETROVIRAL INFECTIVITY, THE COMPOUNDS, AND USES THEREOF |
摘要 |
Retroviruses are RNA viruses that must insert a DNA copy (cDNA) of their genome into the host genome in order to carryout a productive infection. One host cellular pathway that defends against retroviral cDNA integration involves highly conserved proteins of a host DNA repair pathway. These proteins represent novel targets for anti-retroviral drugs. The invention presented herein provides, inter alia, methods of identifying compounds that induce a DNA repair pathway and/or inhibit retroviral cDNA integration into a host genome, compounds thus identified, uses of such compounds, and kits for identifying and testing of the efficacy of compounds in inducing a DNA repair pathway, inhibiting retroviral cDNA integration, and inhibiting retroviral infection. |
申请公布号 |
WO03089573(A3) |
申请公布日期 |
2004.10.28 |
申请号 |
WO2003US10302 |
申请日期 |
2003.04.04 |
申请人 |
FISHEL, RICHARD, A.;YODER, KRISTINE, E. |
发明人 |
FISHEL, RICHARD, A.;YODER, KRISTINE, E. |
分类号 |
C12N15/09;A61K31/7088;A61K39/395;A61K45/00;A61K48/00;A61P3/10;A61P25/00;A61P31/18;A61P35/00;A61P35/02;C07K14/47;C12N5/06;C12N15/867;C12Q1/68;G01N33/50;G01N33/53 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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