发明名称 METHOD FOR THE TREATMENT OF INFERTILITY IN WOMEN AND USE OF FSH THEREFOR
摘要 1. A method for the treatment of infertility in women, comprising administering a patient in need thereof FSH and/or a biologically-active analogue at an initial dose in the range of from 100 to 600 IU followed by a second dose at least 3 days later in the stimulation phase. 2. The method as claimed in claim 1, wherein the FSH and/or a biologically-active analogue thereof is for administration at a dose in the range of from 300 to 600 IU on every third day of the first 6 days of the stimulation phase. 3. The method as claimed in claim 2, wherein the dose is in the range of from 400 to 500 IU. 4. The method as claimed in claim 3, wherein the dose is in the range of from 430 to 470 IU. 5. The method as claimed in claim 3, wherein the dose is about 450 IU. 6. The method as claimed in any one of claims 2 to 5, wherein the medicament is for administration on days 1 and 4, days 2 and 5 or days 3 and 6 of the stimulation phase. 7. The method as claimed in claim 1, wherein the initial dose is in the range of from 100 to 500 IU. 8. The method as claimed in claim 7, wherein the initial dose is in the range of from 200 to 400 IU. 9. The method as claimed in claim 8, wherein the initial dose is about 300 IU. 10. The method as claimed in any one of claims 7 to 9, wherein the second dose is administered between three and six days after the initial dose. 11. The method as claimed in claim 10, wherein the second dose is administered four days after the initial dose. 12. The method as claimed in any one of claims 7 or 8, wherein the second dose is in the range of from 50 to 200 IU. 13. The method as claimed in claim 12, wherein the second dose is in the range of from 70 to 100 IU. 14. The method as claimed in claim 13, wherein the second dose is about 75 IU. 15. The method as claimed in any one of claims 7 to 14, wherein the second dose is repeated daily for 1 to 4 days, preferably 2 days. 16. The method as claimed in any one of claims 7 to 15, wherein the initial dose is administered on day 1, 2, 4 or preferably 3 of the stimulation phase. 17. The method as claimed in any preceding claim, wherein the FSH is recombinant FSH (r-FSH). 18. The method as claimed in any preceding claim, wherein the FSH is human FSH (hFSH).
申请公布号 EA004924(B1) 申请公布日期 2004.10.28
申请号 EA20020000801 申请日期 2001.01.09
申请人 APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. 发明人 LOUMAYE, ERNEST;DUERR-MEYERS, LOUISE
分类号 A61K38/12;A61K38/24;A61P5/06;A61P15/08;(IPC1-7):A61K38/24 主分类号 A61K38/12
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