Purification of amide compound

摘要

An amide compound synthesized through the reaction of a compound having an acyl fluoride group with an amino compound that results in a reaction mixture containing the amide compound and hydrogen fluoride and/or a salt of hydrogen fluoride with the amino compound is purified by adding oxide, carbonate and/or hydroxide of an alkaline earth metal to the mixture to remove the hydrogen fluoride and/or the salt of hydrogen fluoride. Purification of an amide compound synthesized through the reaction of a compound having an acyl fluoride group with an amino compound that results in a reaction mixture containing the amide compound and hydrogen fluoride and/or a salt of hydrogen fluoride with the amino compound involves adding an oxide, carbonate and/or hydroxide of an alkaline earth metal to the reaction mixture to remove the hydrogen fluoride and/or the salt of hydrogen fluoride with the amino compound from the reaction mixture.