| 摘要 |
A compound has the formulain racemic form, enantiomerically enriched form or enantiomerically pure form. R<6 >is preferably -Si(R<8>R<9>R<10>) or -(R<7>)Si(R<8>R<9>R<10>), wherein R<7 >is an alkylene group, an alkenylene group, or an alkynylene group; and R<8>, R<9 >and R<10 >are independently a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, an aryl group or a -(CH2)NR<11 >group, wherein N is an integer within the range of 1 through 10 and R<11 >is a hydroxy group, alkoxy group, an amino group, an alkylamino group, a dialkylamino group, a halogen atom, a cyano group, -SR<c >or a nitro group. R<1>-R<4 >can be broadly substituted. R<5 >is preferably a C1-10 alkyl group, an alkenyl group, an alkynyl group, or a benzyl group. R<13 >is preferably H, F or -CH3. R<16 >is R<16 >is -C(O)R<f >or H. The E-ring (the lactone ring) may be opened. A method of synthesis of compound (1) and intermediates in the synthesis thereof are provided.
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