发明名称 |
Process for the conversion of echinocandin class of peptides to their c4-homotyrosine monodeoxy analogues |
摘要 |
The invention relates to a process for the conversion of echinocandin class of peptides to their C4-homotyrosine monodeoxy analogues, particularly mulundocandin to deoxymulundocandin, which consists of a single step selective reduction of C4-htyr (homotyrosine) hydroxyl group of echinocandins to their monodeoxy analogues under neutral conditions without prior protection/deprotection of the equally facile C5-Orn (ornithine) hydroxyl group and purification of the monodeoxy compound from the crude reaction mixture.
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申请公布号 |
US6809177(B1) |
申请公布日期 |
2004.10.26 |
申请号 |
US20010673836 |
申请日期 |
2001.03.29 |
申请人 |
AVENTIS PHARMA GMBH |
发明人 |
MUKHOPADHYAY TRIPTIKUMAR;JAYVANTI KENIA;KUMAR ERRA KOTESWARA SATYA VIJ |
分类号 |
C07K7/56;(IPC1-7):A61K38/12;A61K38/00;C07K7/00;C12P21/04 |
主分类号 |
C07K7/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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