发明名称 Quinoline derivatives inhibiting the effect of growth factors such as VEGF
摘要 Compounds of the formula (I):wherein: R<2 >represents hydroxy, halogeno, C1-3alkyl, C1-3alkoxy, C1-3alkanoyloxy, trifluoromethyl, cyano, amino or nitro; n is an integer from 0 to 5; Z represents -O-, -NH-, -S- or -CH2-; G<1 >represents phenyl or a 5-10 membered heteroaromatic cyclic or bicyclic group; Y<1>, Y<2>, Y<3 >and Y<4 >each independently represents carbon or nitrogen; R<1 >represents fluoro or hydrogen; m is an integer from 1 to 3; R<3 >represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C1-3alkyl, -NR<4>R<5 >(wherein R<4 >and R<5>, can each be hydrogen or C1-3alkyl), or a group R<6>-X<1>- wherein X<1 >represents -CH2- or a heteroatom linker group and R<6 >is an alkyl, alkenyl or alkynyl chain optionally substituted by for example hydroxy, amino, nitro, alkyl, cycloalkyl, alkoxyalkyl, or an optionally substituted group selected from pyridone, phenyl and a heterocyclic ring, which alkyl, alkenyl or alkynyl chain may have a heteroatom linker group, or R<6 >is an optionally substituted group selected from pyridone, phenyl and a heterocyclic ring and salts thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals such as humans, processes for the preparation of such derivatives, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and compounds of formula I. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.
申请公布号 US6809097(B1) 申请公布日期 2004.10.26
申请号 US19990254440 申请日期 1999.03.09
申请人 ZENECA LTD;ZENECA PHARMA SA 发明人 THOMAS ANDREW PETER;HENNEQUIN LAURENT FRANCOIS AND;PLE PATRICK
分类号 C07D215/20;A61K31/4375;A61K31/47;A61K31/4706;A61K31/4725;A61K31/5377;A61P9/00;A61P9/14;C07D215/22;C07D215/233;C07D215/36;C07D215/42;C07D215/44;C07D215/48;C07D401/12;C07D417/12;C07D471/04;C07D521/00;(IPC1-7):C07D215/22 主分类号 C07D215/20
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