发明名称 |
Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use |
摘要 |
Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and immunoconjugates employing them. Also described are diagnostic and therapeutic methods using the antibodies. The anti-mesothelin antibodies are well-suited for the diagnosis and treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.
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申请公布号 |
US6809184(B1) |
申请公布日期 |
2004.10.26 |
申请号 |
US20000581345 |
申请日期 |
2000.09.27 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
PASTAN IRA H.;CHOWDHURY PARTHA S. |
分类号 |
A61K47/48;C07K16/30;G01N33/574;(IPC1-7):A61K39/395 |
主分类号 |
A61K47/48 |
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