PREVENTIVES OR REMEDIES FOR DISEAES CAUSED BY eNOS EXPRESSION

摘要

The present invention provides a safe therapeutic agent with negligible adverse effects, which activates eNOS so that it optimally functions, and thereby treats or prevents diseases or pathological conditions caused by a condition where the expression product of eNOS gene does not exhibit its proper function. More specifically, the present invention relates to an agent for treating or preventing diseases or pathological conditions caused by an increase in eNOS, which contains, as an active ingredient, a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein each of R<1> and R<2> represents a hydrogen atom, or R<1> and R<2> together form a single bond, and when each of R<1> and R<2> represents a hydrogen atom, R<3> represents -CH(OH)CH(OH)CH3, -CH(OCOCH3)CH(OCOCH3)CH3, -CH3, -CH2OH or a phenyl group, and when R<1> and R<2> together form a single bond, R<3> represents -COCH(OH)CH3.