VIP-ANALOGE

摘要

The present invention encompasses novel analogs of vasoactive intestinal peptide (VIP), containing substitutions at appropriately selected amino acid s. The invention particularly relates to the design and synthesis of novel biologically active VIP analogs containing .alpha., .alpha.-dialkylated amin o acids in a site-specific manner. Specifically, the invention relates to the synthesis of VIP peptide derivatives, which bind selectively to VIP receptor s on target cells. The invention encompasses methods for the generation of the se peptides, compositions containing the peptides and the pharmacological applications of these peptides especially in the treatment and prevention of cancer.