发明名称 PROCESS FOR CRYSTALLISING BUPROPION HYDROCHLORIDE
摘要 <p>Process for crystallising Bupropion hydrochloride comprising the following stages: a) Bupropion hydrochloride is dissolved in a mixture comprising methanol and a precipitating solvent for Bupropion hydrochloride; b) any insoluble residue is removed; c) the solution is distilled at atmospheric pressure until the precipitation reaction is triggered; d) the following are added: I) a precipitating solvent for Bupropion hydrochloride and II) hydrochloric acid until a pH &lt;= 2 is obtained; e) the mass is cooled to a temperature less than 10° C, preferably between 0 and 3° C and the precipitate obtained is separated.</p>
申请公布号 WO2004089873(A1) 申请公布日期 2004.10.21
申请号 WO2004EP50495 申请日期 2004.04.09
申请人 ERREGIERRE S.P.A.;FERRARI, MASSIMO;DE LUCA, FLORINDO;LOMBARDI, FIORELLA 发明人 FERRARI, MASSIMO;DE LUCA, FLORINDO;LOMBARDI, FIORELLA
分类号 C07C221/00;C07C225/16;(IPC1-7):C07C221/00 主分类号 C07C221/00
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