发明名称 NEW NON-IONIC SURFACTANTS FOR SOLUBILIZING POORLY SOLUBLE MOLECULES
摘要 New non-ionic surfactants in the form of polyoxyalkylene glycol hydroxy fatt y acid derivatives or monoalkylated polyoxyalkylene glycol hydroxy fatty acid derivatives having a polyoxyalkylene / alkyl polyoxyalkylene chain with a chain-length of 25 - 455 repeating units and a specified substituent on the hydroxy position of the specified hydroxy fatty acid, according to the gener al formula (I) CH3 - (CH2)x - CH - (CH2)y - CO - [-O - R3 - ]z - O - R1 R2 - O (I); wherein for example R1 is methyl, R2 is optionally substituted C14 - C2 2 acyl, alkyl, or alkenyl, R3 is ethylene, x is 2-12, y is 7-17, (x + y) is 3- 19 and z is 25-57; advantageously prepared by involving an enzymatic process, formulations comprising them, their use as solubilizers and a process involving a hydrolytic enzyme for preparing them.
申请公布号 CA2521612(A1) 申请公布日期 2004.10.21
申请号 CA20042521612 申请日期 2004.04.13
申请人 ASTRAZENECA AB 发明人 CORSWANT, CHRISTIAN VON;HULT, KARL;VIKLUND, FREDRIK;SOEDERLIND, ERIK
分类号 A61K9/00;A61K9/02;A61K9/20;A61K9/48;A61K47/14;C08G65/332;C12P7/62;(IPC1-7):C07C69/66;A61K47/30 主分类号 A61K9/00
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