HETEROARYLSULFONANILIDE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME

摘要

A novel heteroarylsulfonanilide derivative represented by the general formula [I]. It has potent ß3 receptor-stimulating activity, shows excellent selectivity, and is useful as a ß3 adrenergic receptor agonist having excellent pharmacokinetic activity. [I] [R<1> is optionally substituted heteroaryl; R<2> and R<3> are the same or different and each is hydrogen or lower alkyl; and W is a group represented by the formula [II] or the general formula [III]: [II] (R<4a> is hydrogen, etc. and R<5a> is optionally substituted lower alkyl, etc., or R<4a> and R<5a> may be bonded to each other to form linear or branched lower alkylene; and R<6a> is hydrogen, halogeno, etc.) [III] (R<4b> is hydrogen, etc. and R<5b> is hydrogen, optionally substituted lower alkyl, etc., or R<4b> and R<5b> may be bonded to each other to form linear or branched lower alkylene; R<6b> is hydrogen, halogeno, etc.; A is a single bond or optionally fluorinated, linear or branched lower alkylene, etc.; and X is a single bond, oxygen, or sulfur.).]