摘要 |
Live or killed preparations of attenuated mutant Neisseria bacteria, e.g. N. meningitidis, have the following mutations: (a) an auxotrophic attenuating mutation, e.g. AroA or AroB mutation, (b) a capsule mutation, e.g. synX or galE mutation, and also (c) a mutation which reduces bacterial recombination or exogenous DNA uptake, such as RecA and/or comA mutations. The mutants and their preparations can be used in vaccine compositions. |
申请人 |
XENOVA RESEARCH LIMITED;MCCLEAN, CORNELIA, SUZANNA;KEEN, SIMON, WILLIAM;MARTIN, GILLIAN, MAY |
发明人 |
MCCLEAN, CORNELIA, SUZANNA;KEEN, SIMON, WILLIAM;MARTIN, GILLIAN, MAY |