SUBSTITUTED 4-PHENYL-4-[1H-IMIDAZOL-2-YL]-PIPERIDINE DERIVATIVES AND THEIR USE AS SELECTIVE NON-PEPTIDE DELTA OPIOID AGONISTS WITH ANTIDEPRESSANT AND ANXIOLYTIC ACTIVITY

摘要

The present invention relates to the use of 4-phenyl-4-[1H-imidazol-2-yl]- piperidine derivatives according to Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeri c forms thereof, the tautomeric forms thereof and the N-oxide forms thereof as selective non-peptide .delta.-opioid agonists for use in the prevention and/ or treatment of various central nervous system disorders, in particular as selective antidepressant and anxiolytic non-peptide .delta.-opioid agonists. In particular are claimed compounds according to Formula (I) in which A=B is C=O or SO2, X is a covalent bond, R1 is alkyloxy, alkyloxyalkyl, Ar or NR9R1 0, wherein R9 and R10 each independently are hydrogen or Ar ; or A=B and R1 together form a benzoxazolyl radical ; p is zero, R3 is benzyl optionally substituted with hydroxy, alkyl or alkyloxycarbonyl and R4 and R5 each are hydrogen.