METHODS AND COMPOSITIONS FOR PREVENTION, DIAGNOSIS, AND TREATMENT OF CANCER USING BISPECIFIC MOLECULES

摘要

The present invention provides bispecific molecules having a first antigen recognition portion which binds a C3b-like receptor (known as complement receptor 1 (CRl) or CD35 in primates) and a second antigen recognition portion which binds a tumor associated antigen present in the circulation of a mammal. The invention also provides methods of using the bispecific molecules for removing shed tumor associated antigens from the circulation of a mammal. The invention also provides methods of using the bispecific molecules for diagnosis and treatment of cancer.