PROCESS FOR PRODUCING 2'-DEOXY-2'-FLUOROURIDINE

摘要

1-ß-D-Arabinofuranosyluracil in a 3',5'-hydroxy-protected form is reacted with a trifluoromethanesulfonylating agent in the presence of an organic base to convert it into a 2'-triflate form, and this compound is reacted with a fluorinating agent comprising "a salt or complex comprising an organic base and hydrofluoric acid" to produce 2'-deoxy-2'-fluorouridine in a 3',5'-hydroxy-protected form. An agent for eliminating the protective groups is further caused to act on the protected compound to obtain 2'-deoxy-2'-fluorouridine. The 2'-deoxy-2'-fluorouridine obtained can be efficiently purified by temporarily converting it into a 3',5'-diacetyl form, recrystallizing the 3',5'-diacetyl form, and then deacetylating it. Thus, high-purity 2'-deoxy-2'-fluorouridine can be produced.