发明名称 |
Mini-Ad vector for immunization |
摘要 |
The present invention provides a method for treating a disorder such as hemophilia. A method of treating hemophilia in a mammal by administering recombinant virus virions comprising a nucleotide sequence having an adenoviral inverted terminal repeat fusion sequence, a packaging signal, a transcriptional control region, and a nucleic acid encoding a therapeutic protein such as FVIII. In addition, the DNA molecule does not encode an adenoviral protein. It is preferred that the virions be administered to the mammal under conditions that result in the expression of the therapeutic protein at a level that provides a therapeutic effect in said mammal.
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申请公布号 |
US2004208846(A1) |
申请公布日期 |
2004.10.21 |
申请号 |
US20040837079D |
申请日期 |
2004.06.15 |
申请人 |
ZHANG WEI-WEI;ALEMANY RAMON;DAI YIFAN;JOSEPHS STEVEN;BALAGUE CRISTINA;AYARES DAVID;SCHNEIDERMAN RICHARD |
发明人 |
ZHANG WEI-WEI;ALEMANY RAMON;DAI YIFAN;JOSEPHS STEVEN;BALAGUE CRISTINA;AYARES DAVID;SCHNEIDERMAN RICHARD |
分类号 |
A01K67/027;A61K38/00;A61K48/00;C07K14/755;C12N15/85;C12N15/861;(IPC1-7):A61K48/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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