THIAZOLIDINEDIONE COMPOUNDS WITH HYPOGLYCEMIC PROPERTIES

摘要

The compounds invented constitute a new series of thiazolidine derivatives, 5-benzylidene-3-(4-mehyl-benzyl)-thiazolidine-2,4-diones (ATDZs) substituted in benzylidene ring and 5-(1H-indol-3-yl-methylene)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione (ITDZ); all have pharmacological uses and anti-diabetic effects. These, therefore, represent a new series of anti-diabetic agents which act on the nuclear receptor hormone PPARg, exhibiting hypoglycemic properties and potential for therapeutic use as anti-diabetes drugs.