STABLE PHARMACEUTICAL DOSAGE FORM COMPRISING HMG-CoA REDUCTASE INHIBITOR

摘要

The present invention relates to stable pharmaceutical dosage forms comprising the active substances sensitive to environmental influences and pharmaceutical excipients which provide stability of one or more active substance to pH of the environment and do not contain alkalizing or buffering substances or combinations thereof. Said invention also discloses the stable pharmaceutical dosage forms comprising the active substances sensitive to pH of the environment, oxidation and/or environmental humidity, pharmaceutical excipients which provide stability of the active substance to pH of the environment and the coating which provides protection of the active substance from environment influences, in particular from oxidation and/or environmental humidity. Further the invention discloses the procedures for the preparation of the stable pharmaceutical dosage form and use of such active substances for the preparation of the pharmaceutical dosage forms for the treatment of dyslipidemias, cardiovascular disease and other diseases.