PROCESS FOR PRODUCING TABLET

摘要

In a tablet of a drug showing a high pharmacological activity in a small amount, special attention should be paid to the uniformity of its content in the preparation. In such a case, it has been a practice to serially dilute a small amount of the drug with a filler to give a homogeneous mixture or to dissolve the drug in a solvent followed by wet-granulation together with additives. However, the serial dilution method is disadvantageous in production efficiency because of involving many steps, while the wet granulation method frequently suffers from a decrease in the content of the main ingredient in the case of a drug having poor stability to moisture or oxygen. A tablet having a uniform drug content can be produced within a short time without resort to additional steps by uniformly suspending a drug in the form of a fine powder having an average particle size of 1 to 20 mum in a insoluble liquid medium containing a binder, spraying the obtained suspension onto pharmaceutical additive(s) under fluidization to effect fluidized bed granulation, and then compression-molding the grains so as to give a drug content after drying of 0.1 to 10% by weight based on the whole tablet.