发明名称 |
USE OF TFF2, OR AGENTS INDUCING TFF2, IN THE THERAPY OF ALLERGIES |
摘要 |
A composition and method for alleviation of an allergic response by regulation of trefoil factor-2 (TFF2) expression. TFF2 is also disclosed as a marker for assessment of an allergic patient's status, for example, monitoring inflammation and/or tissue repair in a lung of an asthmatic patient. Regulation of TFF2 is involved in the pathogenesis of allergic lung inflammation and other allergen-induced conditions, for example, up-regulation of TFF2 may exert a protective effect by reducing acid secretion and/or increasing epithelial cell proliferation to promote healing. |
申请公布号 |
WO2004064860(A8) |
申请公布日期 |
2004.10.21 |
申请号 |
WO2004US01140 |
申请日期 |
2004.01.16 |
申请人 |
CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER;ROTHENBERG, MARC, ELLIOT |
发明人 |
ROTHENBERG, MARC, ELLIOT |
分类号 |
A61K38/20;A61K38/22;A61P11/06;A61P37/08;(IPC1-7):A61K38/20;A61K38/17;G01N33/00 |
主分类号 |
A61K38/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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