| 摘要 |
<p>The invention relates to compounds of formula (I), which are suitable for the production of medicaments for the prophylaxis and therapy of diseases in the course of which reinforced activity of matrix metalloproteinase 13 is involved. Said diseases include degenerative arthropathy, for example, spondylosis, chondroporosis after joint trauma or prolonged joint immobilization after meniscus or patella injuries or ruptures of a ligament or a disease of the connective tissue such as collagenosis, periodontal diseases, wound healing disorders or a chronic disease of the locomotor system such as acute or chronic inflammatory, immunological or metabolic arthritis, arthropathy, myalgia or bone metabolism disorders or an ulceration, arteriosclerosis or stenosis or an inflammatory disease or a cancer disease, tumor metastasis formation, cachexia, anorexia or septic shock.</p> |
