BETULINSÄURE-DERIVATE UND IHRE VERWENDUNGEN

摘要

Some betulinic acid and dihydrobetulinic acid acyl derivatives according to the present invention have been found to have potent anti-HIV activity. Introducing a C2-C20 substituted or unsubstituted acyl group at the C3-hydroxy group of betulinic acid and dihydrobetulinic acid produces the corresponding 3-O-acyl derivatives. The compounds of the present invention have the following formulae: where R may be a mono- or dicarboxylacyl group, substituted or unsubstituted, of from about 2 to about 20 carbon atoms, and R' may be hydrogen or a C2-C10 substituted and unsubstituted alkyl or aryl group.