发明名称 |
LIPID ASSEMBLIES COMPRISING NON-LIPOSOME FORMING AMPHIPHILES |
摘要 |
The present invention concerns a stable lipid assembly comprising a biologically active lipid having a hydrophobic region and a polar headgroup, wherein the atomic mass ratio between the headgroup and hydrophobic region is less than 0.3, and a lipopolymer having a hydrophobic lipid region and a polymer headgroup, wherein the atomic mass ratio between the headgroup and hydrophobic region is at least 1.5 and optionally a lipid matrix composed of liposome forming lipids. Specific lipid assemblies according to the invention comprise the biologically active lipid, ceramide, a lipid derivatized with polyethylene glycol (lipopolymer) and optionally in combination with a phospholipid (e.g. Egg phosphatidylcholine (EPC) and hydrogenated soybean phosphatidylcholine (HSPC)). The lipid assemblies of the invention exhibited a therapeutic effect in vitro in tumor cells as well as in vivo in animal models and they deliver the biologically active lipid to the disease site. |
申请公布号 |
WO2004087097(A2) |
申请公布日期 |
2004.10.14 |
申请号 |
WO2004IL00294 |
申请日期 |
2004.03.31 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW;BARENHOLZ, YECHEZKEL;KHAZANOV, ELENA;SCHILLEMANS, JORIS |
发明人 |
BARENHOLZ, YECHEZKEL;KHAZANOV, ELENA;SCHILLEMANS, JORIS |
分类号 |
A61K9/00;A61K9/107;A61K9/127;A61K31/164 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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