OSMOTIC DEVICE CONTAINING ZAFIRLUKAST AND A H1 ANTAGONIST

摘要

The invention relates to a controlled release device, e.g. an osmotic device, which releases zafirlukast in a controlled manner and which releases a H1 antagonist in a rapid and/or immediate manner. A wide range of antihistamine H1 antagonists, particularly loratadine, can be used in the inventive device. Specific embodiments of the invention comprise osmotic devices which release zafirlukast and a H1 antagonist in a controlled manner from the nucleus over an extended period of time. The aforementioned devices can be used for the treatment of allergic reactions, inflammation and asthma.