发明名称 |
METHODE OF MANUFACTURING GLIMEPIRIDE AND THE RESPECTIVE INTERMEDIATE |
摘要 |
A method of manufacturing glimepiride of formula I wherein trans-4-methylcyclohexylamine pivalate of formula (VII) is reacted, either directly or after conversion to trans-4-methylcyclohexylamine or to its another salt, with an alkyl [4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-lH-pyrrol-l yl)carbonyl]amino)ethyl)phenyl]-sulfonyl carbamate of general formula (IV) wherein R is a C1-C5 alkyl, giving glimepiride of formula I. trans-4-Methylcyclohexylamine pivalate of formula (VII). |
申请公布号 |
WO2004073585(A3) |
申请公布日期 |
2004.10.14 |
申请号 |
WO2004CZ00009 |
申请日期 |
2004.02.20 |
申请人 |
ZENTIVA, A. S.;RADL, STANISLAV;JARRAH, KAMAL |
发明人 |
RADL, STANISLAV;JARRAH, KAMAL |
分类号 |
A61K;C07C211/35;C07D207/38 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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