RECOMBINANT LENTIVIRALE VECTOR PSEUDOTYPED WITH THE HEMAGGLUTININ PROTEIN FOR GENE TRANSFER INTO THE RETINA

摘要

The present invention relates to a novel lentiviral vector particularly well shaped for performing gene transfer into the retina. These lentiviral vectors are pseudotyped with a HA protein from an orthomyxovirus and comprise one or several gene(s) useful for preventing or treating diseases of the eye. The invention also relates to compositions and methods for preventing or treating diseases of the eye, using the vector of the invention to transfer selected genes suitable for preventing or treating diseases of the eye.