发明名称 |
SELECTIVE ACTIVATION OF CELLULAR ACTIVITIES MEDIATED THROUGH A COMMON TOLL-LIKE RECEPTOR |
摘要 |
Methods of identifying compounds that selectively modulate cellular activities mediated by a common TLR are provided. Generally, the methods include providing an assay to detect modulation of a first cellular activity mediated by a TLR; providing an assay to detect modulation of a second cellular activity mediated by the TLR; performing each assay using a test compound; and identifying the test compound as a compound that selectively modulates at least one cellular activity of a plurality of activities mediated by a common TLR if the test compound modulates the first cellular activity to a different extent than it modulates the second TLR-mediated cellular activity. Compounds identified by such methods, pharmaceutical compositions including such compounds, and methods of treating a condition by administering such pharmaceutical compositions to a subject are also provided. |
申请公布号 |
WO2004087049(A2) |
申请公布日期 |
2004.10.14 |
申请号 |
WO2004US08979 |
申请日期 |
2004.03.24 |
申请人 |
3M INNOVATIVE PROPERTIES COMPANY |
发明人 |
FINK, JASON, R.;GUPTA, SHALLEY, K. |
分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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