2, 4, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES

摘要

The invention relates to substituted pyrimidines of formula (I) wherein V represents a bond or CR<6>R<7>, W represents a bond, NR<8> or oxygen, X represents sulfur, or nitrogen substituted by hydrogen or R<5>, Y represents -CH2-, -CH2CH2-, -CO- or -CS-, R<1> represents unsubstituted or substituted aryl or heteroaryl, and the substituents R<2>, R<3>, R<4>, R<5>, R<6>, R<7> and R<8> have the meanings given in the specification. These compounds are selectively inducing apoptosis in cancer cells and can be used for the treatment of neoplastic and autoimmune diseases. The invention relates also to methods of synthesis of such compounds, to their use as medicaments, to pharmaceutical compositions containing same, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.