COMPOSITIONS COMPRISING MACROLIDE T-CELL IMMUNOMODULATORS ORIMMUNOSUPPRESSANTS IN COMBINATION WITH ANTIBACTERIALS

摘要

Highly compatible or synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and an antibacterial such as sulfasalazin, ciprofloxacin, ofloxacin, erythromycin or gentamycin, optionally with a further pharmaceutically activ e agent, especially a retinoid, are provided, which are useful in particular i n the treatment of diseases involving bacterial or suspected or anticipated bacterial infection, for immunomodulation or immunosuppression in conditions in which bacterial or suspected or anticipated bacterial colonisation of e.g . the skin plays a role, such as atopic, contact and seborrhoeic dermatitis, eczema, psoriasis, acne, rosacea, post-peel, skin burning, itching, or IBD, and in situations of bacterial resistance.