BENZO[1,2,5]OXADIAZOLES AND BENZO [1,2,5]THIADIAZOLES USEFUL AS HISTOPATHOLOGICAL STAINING AGENTS, IMAGING AGENTS AND BIOMARKERS

摘要

The present invention relates to novel benzo[1,2,5]oxadiazoles and benzo[1,2,5]thiadiazoles of formula (I) wherein X is O or S, R1 is 5-(2-fluoro-ethylamino)-thiazol-2-yl, 5-(2-<18>F-ethylamino)- thiazol-2-yl or a group of formula (a) wherein Y is CH or N, R2 is NHCH3, NH<11>CH3, N(CH3)<11>CH3, N(CH3)2, N(<11>CH3)2, NH(CH2)nF, NH(CH2)n<18>F, N(CH3)­(CH2)nF, N(CH3)-(CH2)n <18>F, O-(CH2)nF, O-(CH2)n <18>F, CONH(CH2)nF or CONH(CH2)n<18>F (n being in each case 2 to 4) and R3 is hydroxy, (C1-4)alkoxy, hydrogen or nitro, in free base or acid addition salt form; their preparation, their use as markers in diagnosis and compositions containing them.