Complexes comprising a prion protein and a peptidyl prolyl isomerase chaperone, and method for producing and using them

摘要

The present invention relates to the diagnosis of transmissible spongiform encephalopathies (TSEs). It especially teaches the production of a soluble prion protein (PrP)-chaperone complex and the advantageous use of such chaperone-PrP complex, especially in the detection of PrP in an immunoassay, as well as its use as an immunogen.