There are disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human KDR. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases in which VEGF and/or KDR are implicated.
申请公布号
WO03031475(A8)
申请公布日期
2004.10.14
申请号
WO2002GB04619
申请日期
2002.10.10
申请人
CELLTECH R & D LIMITED;POPPLEWELL, ANDREW, GEORGE;TICKLE, SIMON, PETER;ZINKEWICH-PEOTTI, KAREN;MORRISON, ROBERT, KENDALL