NOVEL NITRILE GLYCOSIDE USEFUL AS A BIO-ENHANCER OF DRUGS AND NUTRIENTS, PROCESS OF ITS ISOLATION FROM MORINGA OLEIFERA.

摘要

The present invention relates to a novel nitrile glycoside of Formula (I) named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula (I) below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula (I) below named NIAZIRIDI N and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (-) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing the ir bio-availability. Therefore niaziridin can be used in combination therapy wi th drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.